Primary biliary cirrhosis (PBC) is an autoimmune condition that results in destruction of the intrahepatic biliary epithelial cells and is characterized by autoantibodies to pyruvate dehydrogenase complex (PDC). The portal tract T-cell infiltrate and up-regulation of HLA class I, HLA class 11, and c
Antibodies to E1 and E2/Protein X components of pyruvate dehydrogenase complex in sera of patients with primary biliary cirrhosis
โ Scribed by Masahito Kuroda; Takao Morito; Tohru Takagi; Hiromasa Ohira; Masae Kokubun; Tosihiko Kojima; Kazuo Ono; Hideo Kochi; Reiji Kasukawa
- Book ID
- 118567463
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 1014 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0168-8278
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๐ SIMILAR VOLUMES
Autoantibodies to the pyruvate dehydrogenase complex (PDC) are present in the serum of more than 95% of patients with primary biliary cirrhosis (PBC), the major epitope being the inner lipoyl domain of the E2 component. Immunoblotting suggests a similar prevalence of antibodies to a tightly associat
tained reactivity toward PDC-E2 and/or BCOADC-E2. Five different target mitochondrial autoantigens rec-Furthermore, affinity-purified PBC sera against recomognized by sera from patients with primary biliary cirbinant OGDC-E2 reacted only with native OGDC-E2 and rhosis (PBC) have been identified as s
Previous studies in which quantitative immunofluorescenm was used have shown that certain biliary epithelial cells in liver with primary biliary cirrhosis show i n d levels of pyruvate dehydrogenase dihyddipoamide acetyltransferase compared with controls. "his study was designed to determine whether