tained reactivity toward PDC-E2 and/or BCOADC-E2. Five different target mitochondrial autoantigens rec-Furthermore, affinity-purified PBC sera against recomognized by sera from patients with primary biliary cirbinant OGDC-E2 reacted only with native OGDC-E2 and rhosis (PBC) have been identified as s
Epitope mapping and reactivity of autoantibodies to the E2 component of 2-oxoglutarate dehydrogenase complex in primary biliary cirrhosis using recombinant 2-oxoglutarate dehydrogenase complex
โ Scribed by S Moteki; PS Leung; ER Dickson; DH Van Thiel; C Galperin; T Buch; D Alarcon-Segovia; D Kershenobich; K Kawano; RL Coppel; S Matuda; ME Gershwin
- Book ID
- 118686129
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 468 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0270-9139
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๐ SIMILAR VOLUMES
Autoantibodies in primary biliary cirrhosis recognize mitochondrial 2-oxacid dehydrogenase complexes, particularly the E2 subunits. Reactivity with the E3 subunit, common to each of the enzyme complexes, was sought by immunoblotting, with sera screened at 1:100 instead of the conventional 1:1,000 di
S i x components of the mammalian 2-0x0 acid dehydrogenase complexes have previously been identified as M2 autoantigens in primary biliary cirrhosis. In this report, we present data showing that both polypeptidespecific and cross-reacting antibodies are present in patients' sera. Antibodies reacting