Antibodies to colony-stimulating factors block Lewis lung carcinoma cell stimulation of immune-suppressive bone marrow cells
β Scribed by M. Rita I. Young; Mark A. Wright; Melvin E. Young
- Publisher
- Springer-Verlag
- Year
- 1991
- Tongue
- English
- Weight
- 1003 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0340-7004
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π SIMILAR VOLUMES
Using both polymerase-chain-reaction analysis and the softagar colony-forming unit assay, granulocyte-macrophage colonystimulating factor (GM-CSF) was shown to be expressed by cloned metastatic Lewis-lung-carcinoma (LLC-LN7) cells but not by non-metastatic LLC-C8 cells. Furthermore, the metastatic L
Kosaka, K. (1977) Demonstration of granulopoietic factods) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue. Blood, 49:845-852. Apte, R.N., and Pluznik, D.H. (1976) Genetic control of lipopolysaccharide induced generation of serum colony stimulating factor and
Expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) by metastatic Lewis lung carcinoma cells (LLC-LN7) was previously shown to contribute to the maintenance of phenotypic characteristics associated with an increased capacity t o metastasize. In the present study, pre-incubation o
## Abstract The roles of colonyβstimulating factors in longβterm bone marrow cultures were studied and compared. After single additions of high concentrations of unpurified colonyβstimulating activities to the cultures, rapid deterioration of the cultures was observed. This appears to result from c