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Antibodies to colony-stimulating factors block Lewis lung carcinoma cell stimulation of immune-suppressive bone marrow cells

✍ Scribed by M. Rita I. Young; Mark A. Wright; Melvin E. Young


Publisher
Springer-Verlag
Year
1991
Tongue
English
Weight
1003 KB
Volume
33
Category
Article
ISSN
0340-7004

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Using both polymerase-chain-reaction analysis and the softagar colony-forming unit assay, granulocyte-macrophage colonystimulating factor (GM-CSF) was shown to be expressed by cloned metastatic Lewis-lung-carcinoma (LLC-LN7) cells but not by non-metastatic LLC-C8 cells. Furthermore, the metastatic L

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## Abstract The roles of colony‐stimulating factors in long‐term bone marrow cultures were studied and compared. After single additions of high concentrations of unpurified colony‐stimulating activities to the cultures, rapid deterioration of the cultures was observed. This appears to result from c