Antibodies to collagen in patients with leprosy
β Scribed by Keith P.W.J. McAdam; H. Hugh Fudenberg; Dov Michaeli
- Book ID
- 118373458
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- English
- Weight
- 412 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1090-2341
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In the sera of patients with lepromatous leprosy anti-DNP antibodies were detected in order to determine the mode of polyclonal B-cell activation. Anti-DNP antibodies were found in 30% of the patients with active lepromatous leprosy and in 8% of those with inactive lepromatous leprosy. The level of
## Abstract Using the enzymeβlinked immunosorbent assay (ELISA), we detected antibodies to interstitial (type I) and basement membrane (type IV) collagens in the sera of patients with scleroderma (systemic sclerosis). Antibodies against type IV collagen were found in significant levels in these pat
In 79 patients with leprosy a significant increase of anti-extractable nuclear antigen (ENA) antibodies and circulating immune complexes (CIC) was found. No correlation between CIC and anti-ENA antibodies was demonstrable. Since such a correlation is known from antinuclear antibodies and CIC in pati