Antibodies in scleroderma: Direct pathogenicity and phenotypic associations
β Scribed by Lorinda Chung; Paul J. Utz
- Book ID
- 107553721
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 388 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1523-3774
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Patients selected for the presence of sclerodermarelated antibodies (anti-DNA-topoisomerase I [anti-top0 I; n = 431, anticentromere antibody [ACA; n = 631, or anti-Pm-Scl [n = 121) were studied for class I and class I1 major histocompatibility complex antigens, as well as for Gm and Km allotypes. An
## Abstract Using the enzymeβlinked immunosorbent assay (ELISA), we detected antibodies to interstitial (type I) and basement membrane (type IV) collagens in the sera of patients with scleroderma (systemic sclerosis). Antibodies against type IV collagen were found in significant levels in these pat
When HeLa cells were used as the substrate for detection by the indirect immunofluorescence method, antinuclear antibodies were demonstrated in 16 of 22 (72.7%) sera from patients with localized scleroderma. When mouse kidney sections were used, the positive rate for antinuclear antibodies was 50% (