Immunogenetic associations of scleroderma-related antinuclear antibodies

✍ Scribed by Ekkehard Genth; Rudolf Mierau; Petra Genetzky; Carlos A. Von Mühlen; Sidonie Kaufmann; Hubertus Von Wilmowsky; Michael Meurer; Thomas Krieg; Hans-Joachim Pollmann; Paul Walter Hartl

• Book ID: 102753977
• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 747 KB
• Volume: 33
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780330508

✦ Synopsis

Patients selected for the presence of sclerodermarelated antibodies (anti-DNA-topoisomerase I [anti-top0 I; n = 431, anticentromere antibody [ACA; n = 631, or anti-Pm-Scl [n = 121) were studied for class I and class I1 major histocompatibility complex antigens, as well as for Gm and Km allotypes. AntLtopo 1 was associated with HLA-DR5 (70% of patients versus 30.6% of controls; Pcorr = 0.0018, relative risk [RR] = 5.3). All patients with anti-Pm-Scl were positive for HLA-DR3 (versus 23.5% of controls; f,,,, < 0.001); 6 of these patients were DR3/4 heterozygous (50% versus 3.5% of controls; Pmm < 0.001, RR = 27.3). Patients with ACA were frequently positive for HLA-DRI, DR4, or DRw8, with 73.7% demonstrating at least 1 of these alleles (versus 41.2% of controls; Pcor, = 0.0152, RR = 4.0). This group of ACA-positive patients who had DRI, -~