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Antibiotics from Gliding Bacteria, XLVII. Thiangazole: A Novel Inhibitor of HIV-1 fromPolyangium spec.

✍ Scribed by Jansen, Rolf ;Kunze, Brigitte ;Reichenbach, Hans ;Jurkiewicz, Elke ;Hunsmann, Gerhard ;Höfle, Gerhard

Book ID
102365320
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
339 KB
Volume
1992
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

Using a biological screening with a HIV‐1/MT‐4 cell assay indicating antiviral activity and cell toxicity, we detected and isolated a new inhibiting metabolite from gliding bacteria, thiangazole (1). The structure of 1 was determined by spectroscopic methods to be a tris(thiazoline) derivative, showing a remarkable similarity to tantazole B (2). Chemical degradation and comparison with a synthetically prepared reference compound as well as with the degradation product from 2 furnished the (5__R__,8__S__,11__S__) configuration of the asymmetric centers in 1.

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