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Antibiotics from Gliding Bacteria, LXIII. Ratjadone: A New Antifungal Metabolite fromSorangium cellulosum

✍ Scribed by Schummer, Dietmar ;Gerth, Klaus ;Reichenbach, Hans ;Höfle, Gerhard

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
349 KB
Volume
1995
Category
Article
ISSN
0947-3440

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✦ Synopsis

Antibiotics I Sorangium cellulosum I Myxobacteria I Antifungal agent I Biosynthesis

The antifungal metabolite ratjadone (1) was isolated from the myxobacterium Sorangium cellulosum, strain So ce360. Production was achieved by fermentation in the presence of the adsorber resin XAD-16, extraction and separation by RP chromatography. The structure of 1 was determined by spec-troscopic methods. It is characterized by a 4-hydroxytetrahydropyran and a 5,6-dihydropyran-2-one ring which are connected by an unsaturated C1, carbon chain. The polyketide origin of 1 was proven by feeding experiments with I3C-labeled precursors and NMR spectroscopic examinations. ' " 1 5 1 3 1 1 9 7 ' 0 Longe range correlations in the COLOC spectrum (Figure 2) finally corroborated the connections of the carbons

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