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Antibiotics from gliding bacteria, LVII. Tartrolons: New boron-containing macrodiolides fromSorangium cellulosum

✍ Scribed by Schummer, Dietmar ;Irschik, Herbert ;Reichenbach, Hans ;Höfle, Gerhard

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
637 KB
Volume
1994
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

The antibacterial metabolites tartrolon A~1~, A~2~, A~3~ (1a–1c) and B (2) were isolated from the myxobacterium Sorangium cellulosum, strain So ce678. Large‐scale production was achieved by fermentation in the presence of the adsorber resin XAD‐16, extraction, and separation by RP chromatography followed by crystallization. The 42‐membered macrodiolide structure of 1a–1c and 2 was determined by spectroscopic methods. Compound 2 was identified as a boric acid ester of 1c, whereas 1a and 1b are stereoisomers of 1c. All components could be chemically converted into each other. A correlation between the production of 2 and the borate concentration in the medium was found, depending on nutrients and container material used. magnified image

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