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Antibacterial constituents from the rhizomes of Ferula communis

✍ Scribed by Mohammed A. Al-Yahya; Ilias Muhammad; Humayun H. Mirza; Farouk S. El-Feraly

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 126 KB
Volume: 12
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199808)12:5<335::aid-ptr306>3.0.co;2-h

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✦ Synopsis

The rhizomes of Ferula communis yielded three antibacterial sesquiterpenes, namely, the new daucane ester 14-(o-hydroxycinnamoyloxy)-dauc-4,8-diene (1), ferulenol (2) and ferchromone (3). Compound 1 exhibited significant activity against Gram-positive bacteria, while 3 was found to be less active. Compound 2, on the other hand, demonstrated potent activity against Mycobacterium organisms, and its corresponding C-4-acetoxy derivative 9 was found to retain the same activity as well. In addition, the rhizomes yielded a number of inactive compounds, including 2-nor-1,2-secoferulenol, elemicin, colladonin, feselol and compounds 4 and 5. Structural assignments were largely based on the spectral data, especially the 2D NMR COSY and HETCOR experiments.

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