Antibacterial activity of a pepsin-derived bovine hemoglobin fragment
β Scribed by R. Froidevaux; F. Krier; N. Nedjar-Arroume; D. Vercaigne-Marko; E. Kosciarz; C. Ruckebusch; P. Dhulster; D. Guillochon
- Book ID
- 117102750
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 112 KB
- Volume
- 491
- Category
- Article
- ISSN
- 0014-5793
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## Abstract We have investigated the effects of charge and lipophilicity on the antibacterial activity of an undecapeptide (FKCRRWQWRMK) derived from the sequence of bovine lactoferricin. We prepared ten analogues that were modified by the incorporation of Ala, Tyr, Trp, Met and Arg residues, which
## Abstract A model peptide, FKCRRWQWRMKKLGA, residues 17β31 of bovine lactoferricin, has been subjected to structureβantibacterial activity relationship studies. The two Trp residues are very important for antibacterial activity, and analogue studies have demonstrated the significance of the size,