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Antiarrhythmic effects of amiodarone and its metabolite desethylamiodarone in conscious rats

✍ Scribed by I. Bódi; A. Barró; G. Schmidt; G. Rabloczky

Book ID
119442195
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
77 KB
Volume
19
Category
Article
ISSN
0022-2828

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## Abstract The pharmacokinetics of desethylamiodarone (DEA), the active metabolite of amiodarone (AM), were studied in the rat after administration of AM or preformed metabolite. Rats received 10 mg/kg of either intravenous or oral AM HCl or DEA base. Blood samples were obtained via a surgically i