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Effects of Amiodarone and Its Active Metabolite Desethylamiodarone on the Ventricular Defibrillation Threshold

✍ Scribed by Li Zhou; Bonnie P Chen; Jeffrey Kluger; Chengde Fan; Moses S.S Chow

Book ID: 118588229
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 127 KB
Volume: 31
Category: Article
ISSN: 1558-3597
DOI: 10.1016/s0735-1097(98)00160-0

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## Abstract The pharmacokinetics of desethylamiodarone (DEA), the active metabolite of amiodarone (AM), were studied in the rat after administration of AM or preformed metabolite. Rats received 10 mg/kg of either intravenous or oral AM HCl or DEA base. Blood samples were obtained via a surgically i