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Effect of Amiodarone and Desethylamiodarone on the Pharmacokinetics of Antipyrine in the Rat

✍ Scribed by Craig K. Svensson; Li-Ling Liu; Philip W. Knowlton

Book ID
114421431
Publisher
Springer US
Year
1987
Tongue
English
Weight
539 KB
Volume
04
Category
Article
ISSN
0724-8741

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## Abstract The pharmacokinetics of desethylamiodarone (DEA), the active metabolite of amiodarone (AM), were studied in the rat after administration of AM or preformed metabolite. Rats received 10 mg/kg of either intravenous or oral AM HCl or DEA base. Blood samples were obtained via a surgically i