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Anti-oxidant sensitivity of donor age-related gene expression in cultured fibroblasts

✍ Scribed by Branko Braam; Miriam Langelaar-Makkinje; Arie Verkleij; Hans Bluyssen; Theo Verrips; Hein A. Koomans; Jaap A. Joles; Jan Andries Post


Book ID
113586218
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
273 KB
Volume
542
Category
Article
ISSN
0014-2999

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Alterations in the molecular response to
✍ Augustine M. K. Choi; Robert J. Pignolo; Colette M. J. Ap Rhys; Vincent J. Crist πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 993 KB

Transcriptional activation of c-fos in response to both serum stimulation and D N A damage requires the serum response element. The inability of in vitro aged or senescent fibroblasts to proliferate in response to serum has been shown to be associated with repressed c-fos expression and reduced AP-1