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Anti-metastatic efficacy and safety of MMI-166, a selective matrix metalloproteinase inhibitor

โœ Scribed by Ryuji Maekawa; Hideo Maki; Tohru Wada; Hiroshi Yoshida; Kazuyo Nishida-Nishimoto; Hiroyuki Okamoto; Yayoi Matsumoto; Hiroshige Tsuzuki; Takayuki Yoshioka


Book ID
111564825
Publisher
Springer
Year
2000
Tongue
English
Weight
80 KB
Volume
18
Category
Article
ISSN
0262-0898

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Antitumor effect of a new selective matr
โœ A. Matsushita; M. Onda; E. Uchida; R. Maekawa; T. Yoshioka ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 402 KB

The antitumor effect of a new matrix metalloproteinase inhibitor, MMI-166, which is a selective inhibitor of MMP-2 and -9, was examined in the hamster pancreatic cancer cell line PGHAM-1. In vitro, MMI-166 inhibited the gelatinase activity of MMP-2 and -9 derived from PGHAM-1 cells, and dose-depende