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Anti-invasive Effect of MMI-166, a New Selective Matrix Metalloproteinase Inhibitor, in Cervical Carcinoma Cell Lines

โœ Scribed by Masahiro Iwasaki; Akira Nishikawa; Takashi Fujimoto; Noriyuki Akutagawa; Kengo Manase; Toshiaki Endo; Koichi Yoshida; Ryuji Maekawa; Takayuki Yoshioka; Ryuichi Kudo


Book ID
112248848
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
116 KB
Volume
85
Category
Article
ISSN
0090-8258

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โœ A. Matsushita; M. Onda; E. Uchida; R. Maekawa; T. Yoshioka ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 402 KB

The antitumor effect of a new matrix metalloproteinase inhibitor, MMI-166, which is a selective inhibitor of MMP-2 and -9, was examined in the hamster pancreatic cancer cell line PGHAM-1. In vitro, MMI-166 inhibited the gelatinase activity of MMP-2 and -9 derived from PGHAM-1 cells, and dose-depende