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Prevention of liver metastasis of human colon cancer by selective matrix metalloproteinase inhibitor MMI-166

✍ Scribed by Kouji Oba; Hiroyuki Konno; Tatsuo Tanaka; Megumi Baba; Kinji Kamiya; Manabu Ohta; Takeshi Kaneko; Tsuyoshi Shouji; Akira Igarashi; Satoshi Nakamura


Book ID
117467127
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
346 KB
Volume
175
Category
Article
ISSN
0304-3835

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✍ A. Matsushita; M. Onda; E. Uchida; R. Maekawa; T. Yoshioka πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 French βš– 402 KB

The antitumor effect of a new matrix metalloproteinase inhibitor, MMI-166, which is a selective inhibitor of MMP-2 and -9, was examined in the hamster pancreatic cancer cell line PGHAM-1. In vitro, MMI-166 inhibited the gelatinase activity of MMP-2 and -9 derived from PGHAM-1 cells, and dose-depende