Anti-GM1 ganglioside antibodies with differing fine specificities in patients with multifocal motor neuropathy
β Scribed by H. Baba; G.C. Daune; A.A. Ilyas; A. Pestronk; D.R. Cornblath; V. Chaudhry; J.W. Griffin; R.H. Quarles
- Book ID
- 119107444
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 678 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0165-5728
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Increased titers of anti-GM1 antibodies have been associated with motor neuron disease and motor neuropathy with or without conduction block. To investigate the pathogenetic role of anti-GM1 antibodies we injected into rat tibial nerves sera from patients with multifocal motor neuropathy and conduct
Low affinity anti-GM 1 IgM-antibodies are part of the normal repertoire of human plasma antibodies (Mizutamari et al.: J Neuroimmunol 50:215-220, 1994), a fact that is against the pathological role proposed for them in autoimmune diseases. Here we present evidence that these low affinity IgM-antibod