Increased titers of anti-GM1 antibodies have been associated with motor neuron disease and motor neuropathy with or without conduction block. To investigate the pathogenetic role of anti-GM1 antibodies we injected into rat tibial nerves sera from patients with multifocal motor neuropathy and conduct
A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside
β Scribed by Dr. A. Pestronk; D. R. Cornblath; A. A. Ilyas; H. Baba; R. H. Quarles; J. W. Griffin; K. Alderson; R. N. Adams
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 614 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0364-5134
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Low affinity anti-GM 1 IgM-antibodies are part of the normal repertoire of human plasma antibodies (Mizutamari et al.: J Neuroimmunol 50:215-220, 1994), a fact that is against the pathological role proposed for them in autoimmune diseases. Here we present evidence that these low affinity IgM-antibod
We tested monoclonal IgM anti-GM1 and asialo-GM1 antibodies from 6 patients with chronic motor neuropathies for binding to lipopolysaccharides (LPS) from three strains of Campylobacter jejuni. Four of the 6 patients showed strong reactivity with LPS from at least one of the three C . jejuni strains