Monoclonal IgM antibodies to GM1 and asialo-GM1 in chronic neuropathies cross-react with Compylobacter jejuni lipopolysaccharides
✍ Scribed by I. Wirguin; Lj. Suturkova-Milosevic; P. Della-Latta; T. Fisher; R. H. Brown Jr; Dr. N. Latov
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 605 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
✦ Synopsis
We tested monoclonal IgM anti-GM1 and asialo-GM1 antibodies from 6 patients with chronic motor neuropathies for binding to lipopolysaccharides (LPS) from three strains of Campylobacter jejuni. Four of the 6 patients showed strong reactivity with LPS from at least one of the three C . jejuni strains tested as shown by enzyme-linked immunosorbent assay or western blot. Preabsorption with GM1 or asialo-GM1, or blocking with cholera toxin, prevented antibody binding to LPS. These studies indicate that human anti-GM1 or anti-asialo-GM1 antibodies cross-react with LPS from certain strains of C . jejuni, and that bacterial LPS might provide antigenic stimuli for the activation of B cells expressing anti-GM1 antibodies.