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Anti-CD3 clinical trials in type 1 diabetes mellitus

✍ Scribed by Daifotis, Anastasia G.; Koenig, Scott; Chatenoud, Lucienne; Herold, Kevan C.


Book ID
121204523
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
472 KB
Volume
149
Category
Article
ISSN
1090-2341

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## Abstract The use of anti‐CD3 monoclonal antibodies (mAbs) has moved from the bench to the bedside. The experience with the anti‐human CD3 mAb OKT3 for treatment of transplant rejection identified limitations that were largely overcome with the creation of humanized non‐FcR binding antibodies: Te