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Anti-amyloidogenic activity of tetracyclines: In vitro studies

✍ Scribed by Forloni, Gianluigi; Colombo, Laura; Girola, Laura; Tagliavini, Fabrizio; Salmona, Mario

Book ID
123376143
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
183 KB
Volume
21
Category
Article
ISSN
0197-4580

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## Abstract Overproduction of the peptide amyloid Ξ² (AΞ²) is thought to be a critical pathogenic event in Alzheimer's disease (AD), leading to the formation of senile (amyloid) plaques, which in turn lead to neurofibrillary tangles, neuronal and synaptic loss, and dementia. Mendelian inheritance of