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Anti-amyloidogenic activity of tetracyclines: studies in vitro

✍ Scribed by Gianluigi Forloni; Laura Colombo; Laura Girola; Fabrizio Tagliavini; Mario Salmona

Book ID
117102606
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
305 KB
Volume
487
Category
Article
ISSN
0014-5793

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## Abstract Overproduction of the peptide amyloid Ξ² (AΞ²) is thought to be a critical pathogenic event in Alzheimer's disease (AD), leading to the formation of senile (amyloid) plaques, which in turn lead to neurofibrillary tangles, neuronal and synaptic loss, and dementia. Mendelian inheritance of