The antineoplastic activity and challenging structural features of the anthracycline antibiotics have caused extensive efforts to be directed toward their chemical synthesis. 2 In particular, Adriamycin (la) and daunomycin (lb) have become the focus of much attention. excellent contributions in thi
Anthracyclines. II - regiospecific synthesis of 6-deoxyanthracycline intermediates
β Scribed by Jean-Pierre Gesson; Jean-Claude Jacquesy; Martine Mondon
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 212 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
## Abstract A new synthetic approach for the regiospecific alkylation of the 6βposition of the tropane ring system has been developed. Alkylation, desulfonylation and deprotection of tropanes 5 and 12 furnished a series of 6β__endo__βalkyltropanβ2βone derivatives 8aβe, 15aβe and 16aβe (R = Me, Et,
## Abstract For Abstract see ChemInform Abstract in Full Text.
The pyrazine ring was developed in a pyrimidine and in a benzene by Isay type condensations under microwave irradiation to afford pterin and quinoxaline systems. Interestingly, the desired isomerically free 6-substituted pterins including pterin sugar derivatives were synthesised in moderate to good