The modifying effects of dimethylarsinic acid (DMA) on tumor induction in various organs were examined using a multi-organ rat carcinogenesis bioassay. A total of 124 six-week-old male F344/DuCrj rats were divided randomly into seven groups. For establishment of wide-spectrum initiation, animals in
✦ LIBER ✦
Antagonistic interactions of an arsenic-containing mixture in a multiple organ carcinogenicity bioassay
✍ Scribed by Wendy A Pott; Stephen A Benjamin; Raymond S.H Yang
- Book ID
- 117469211
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 163 KB
- Volume
- 133
- Category
- Article
- ISSN
- 0304-3835
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## Abstract A single intratracheal 0.1‐ml instillation of a calcium‐arsenate containing vineyard pesticide induced multi‐focal bronchogenic adenocarcinomas and bronchiolar‐alveolar‐cell carcinomas in nine out of 15 treated BD rats. This seems to be the first experimental confirmation of carcinogeni