Enhancing effects of an organic arsenic compound, dimethylarsinic acid (cacodylic acid), in a multi-organ carcinogenesis bioassay
✍ Scribed by Shinji Yamamoto; Yoshitsugu Konishi; Takashi Murai; Masa-Aki Shibata; Tsutomu Matsuda; Koichi Kuroda; Ginji Endo; Shoji Fukushima
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 254 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0268-2605
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✦ Synopsis
The modifying effects of dimethylarsinic acid (DMA) on tumor induction in various organs were examined using a multi-organ rat carcinogenesis bioassay. A total of 124 six-week-old male F344/DuCrj rats were divided randomly into seven groups. For establishment of wide-spectrum initiation, animals in Groups 1-5 were treated with five carcinogens, namely N-nitrosodiethylamine (DEN), N-methyl-N-nitrosourea (MNU), 1,2-dimethylhydrazine (DMH), N-butyl-N-(4hydroxybutyl)nitrosamine (BBN) and N-bis( 2-hydroxypropy1)nitrosamine (DHPN) in the first four weeks. After a two-week interval, Groups 1- 5 were then given 0, 50, 100, 200 and 400ppm DMA, respectively, in drinking water. Groups 6 and 7 received 100 and 400 ppm DMA without any carcinogen pretreatment. All rats were sacrificed at the end of week 30. In the initiated groups (Groups 1-5), DMA enhanced tumor development in the urinary bladder, kidney, liver and thyroid gland. The main arsenic species in urine samples was DMA itself. In conclusion, the observed enhancement of carcinogenesis in the urinary tract as well as in the liver and thyroid gland may be directly due to this arsenic compound.