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Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1

โœ Scribed by Albertoni, Michele; Shaw, Phillip H; Nozaki, Michimasa; Godard, Sophie; Tenan, Mirna; Hamou, Marie-France; Fairlie, Douglas W; Breit, Samuel N; Paralkar, Vishwas M; de Tribolet, Nicolas


Book ID
110066788
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
308 KB
Volume
21
Category
Article
ISSN
0950-9232

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## Abstract Low oxygen tension can influence tumor progression by enhancing angiogenesis, a process that may involve Rho GTPases whose activities have been implicated in tumorigenesis and metastasis. In the present study, we show that hypoxia can increase the mRNA levels and intracellular activitie