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p53-independent induction of p21waf1/cip1 contributes to the activation of caspases in GTP-depletion-induced apoptosis of insulin-secreting cells

✍ Scribed by Huo, J X; Metz, S A; Li, G D


Book ID
110016643
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
397 KB
Volume
11
Category
Article
ISSN
1350-9047

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Codon 273 is one of the hot spots of missense mutation of the p53 tumor suppressor gene found in human cancers. We have previously reported that a mutation at codon 273, p53-273L (Arg 3 Leu), suppresses cell growth despite its having no p53-specific transactivation activity. To further elucidate the