The p53-inducible cyclin-dependent kinase inhibitor, p2 I / WAFI/CIPI (p2I), plays a pivotal role in the GI arrest or apoptosis of cells expored to genotoxic stimuli. To determine whether p2 I is a putative tumor-suppressor gene, p2 I status was investigated in 4 human bladder-cancer cell lines of k
β¦ LIBER β¦
p53-dependent apoptosis or growth arrest induced by different forms of radiation in U2OS cells: p21WAF1/CIP1 repression in UV induced apoptosis
β Scribed by Allan, Lindsey A; Fried, Mike
- Book ID
- 110062330
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 395 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Tumor suppressor p53 is an essential regulator in mammalian cellular responses to DNA damage including cell cycle arrest and apoptosis. Our study with Chinese hamster ovary CHOβK1 cells indicates that when p53 expression and its transactivation capacity was inhibited by siRNA, UVCβinduc