With the use of [ 3 H]gamma-hydroxybutyric acid, binding experiments allowed the screening of new compounds as ligands of gammahydroxybutyric acid receptors. Starting from the acid-alcohol gamma-hydroxybutyric acid structure, structure-activity relation analysis and lead optimization highlighted gam
✦ LIBER ✦
AnIn VivoApproach to Structure Activity Relationship Analysis of Peptide Ligands
✍ Scribed by Xiaomin Fan; Ruben Venegas; Robert Fey; Henri van der Heyde; Mark A. Bernard; Elias Lazarides; Catherine M. Woods
- Publisher
- Springer US
- Year
- 2007
- Tongue
- English
- Weight
- 385 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0724-8741
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## Abstract We have __de novo__ designed four antimicrobial peptides AMP‐A/B/C/D, the 51‐residues peptides, which are based on the conserved sequence of cecropin. In the present study, the four peptides were chemically synthesized and their activities assayed. Their secondary structure, amphipathic