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Angiogenesis in follicular tumors of the thyroid

✍ Scribed by Segal, Karl; Shpitzer, Thomas; Feinmesser, Meora; Stern, Yoram; Feinmesser, Raphael

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 324 KB
Volume: 63
Category: Article
ISSN: 0022-4790
DOI: 10.1002/(sici)1096-9098(199610)63:2<95::aid-jso5>3.0.co;2-j

No coin nor oath required. For personal study only.

✦ Synopsis

Background:

Experimental evidence suggests that tumor growth beyond a certain size and tumor ability to metastasize depend on the degree to which the tumor can stimulate an angiogenic response.

Methods:

Fifteen thyroid specimens of microinvasive follicular carcinoma were examined for vascularization by immunohistochemical stain with antifactor viii antibodies and compared with an equal number of follicular adenomas.

Results:

Pleomorphic areas in the histological specimens of follicular carcinomas had a higher rate of vascularization as did areas of tumor adjacent to or penetrating the capsule. these features were not noted in follicular adenomas.

Conclusions:

Our findings indicate that vascularity may play a role in extracapsular extension and tumor aggression in follicular thyroid carcinomas.

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