Metalloproteinase-9 immunoexpression and angiogenesis in thyroid follicular neoplasms: Relation to clinical and histopathologic features
✍ Scribed by Celso Ubirajara Moretto FrigugliettI; Evandro Sobroza Mello; Inês Vieira Castro; GIlberto Britto Silva Filho; Venâncio Avancini Ferreira Alves
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 257 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1043-3074
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✦ Synopsis
Background. Thyroid follicular neoplasms (adenoma and carcinoma) may pose considerable difficulties to the differential diagnosis. Because such a distinction is not possible at fine-needle aspiration, surgery is often necessary. Clinical information such as age, sex, and node size is important in case of suspected carcinoma. Follicular carcinoma is characterized by capsular invasion, vascular invasion, and metastatic dissemination mainly by the hematogenic pathway. This invasion depends on collagen degradation in capsule and in subendothelial basement membrane. Collagen degradation has been widely researched in the angiogenesis process and in the hematogenic dissemination mechanism. In this study, we performed clinical and histopathologic assessment of 74 follicular neoplasms, as well as immunohistochemical reactions for CD-34 protein to estimate angiogenesis and for metalloproteinase-9, an enzyme that degrades type IV collagen.