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Anemonin, from Clematis crassifolia, potent and selective inducible nitric oxide synthase inhibitor

✍ Scribed by Tzong Huei Lee; Nai Kuei Huang; Tzi Chung Lai; Aleck T.Y. Yang; Guei Jane Wang


Book ID
116643831
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
690 KB
Volume
116
Category
Article
ISSN
0378-8741

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A series of substituted 2iminopyrrolidines is prepared and evaluated as selective inhibitors of the human inducible isoform of nitric oxide synthase (NOS). The most potent analogue is (VI). The compound (+)-(VIII) is also a good inhibitor of human inducible NOS and potent in vivo in mouse models of