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Analysis of the Structure, Transcripts, and Protein Products of bcl-2, the Gene Involved in Human Follicular Lymphoma

✍ Scribed by Yoshihide Tsujimoto and Carlo M. Croce

Book ID
123633123
Publisher
National Academy of Sciences
Year
1986
Tongue
English
Weight
960 KB
Volume
83
Category
Article
ISSN
0027-8424

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We report a new class of molecular lesions in the 5' region of the BCL2 protooncogene when it undergoes a t( 14; 18) translocation-associated rearrangement in the major break cluster (MBR) or minor break cluster (MCR) regions. Among 52 tumors assayed for BCL2 rearrangements using the MBR, MCR, and 5