THE ROLE OF THE bcl-2 GENE IN LYMPHOMA
โ Scribed by Finbarr E. Cotter
- Book ID
- 114712174
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 554 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0007-1048
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We report a new class of molecular lesions in the 5' region of the BCL2 protooncogene when it undergoes a t( 14; 18) translocation-associated rearrangement in the major break cluster (MBR) or minor break cluster (MCR) regions. Among 52 tumors assayed for BCL2 rearrangements using the MBR, MCR, and 5
Background. Only a small percentage of Asian patients with non-Hodgkin lymphoma may have follicular type disease. According to molecular analysis done recently, the incidence of rearrangement of bcl-2 gene in patients with follicular lymphoma was lower in Japan than in the United States, suggesting