Analysis of the mechanism of isoniazid-induced developmental toxicity with frog embryo teratogenesis assay: Xenopus (FETAX)
β Scribed by Douglas J. Fort; John A. Bantle
- Book ID
- 112213469
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 690 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0270-3211
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The developmental toxicity of thalidomide was evaluated using FETAX (Frog Embryo Teratogenesis Assay - Xenopus). Young X. Laevis embryos were exposed to this compound in each of two concentration-response experiments with and without differently induced exogenous metabolic activation systems (MASs)
## Abstract Frog Embryo Teratogenesis Assayβ__Xenopus__ (FETAX) is a 4βday, alternative developmental toxicity assay designed to preβscreen chemicals and environmental mixtures. An approach used in the scoring of FETAX results, which focuses on the determination of characteristic abnormalities indu
The potential teratogenic hazard of five compounds was evaluated using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX) and a metabolic activation system. Embryos of the South African clawed frog, Xenopus laevis, were exposed to (i) three compounds suspected to be proteratogenic in mammalian test