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Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2

✍ Scribed by Thorsten Buhrke; Imme Lengler; Alfonso Lampen


Book ID
108944278
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
552 KB
Volume
53
Category
Article
ISSN
0012-1592

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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi