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Decreased expression of P-glycoprotein during differentiation in the human intestinal cell line Caco-2

✍ Scribed by Maki Goto; Satohiro Masuda; Hideyuki Saito; Ken-ichi Inui


Book ID
113993554
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
368 KB
Volume
66
Category
Article
ISSN
0006-2952

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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi