Analysis of procainamide hydrochloride and acecainide hydrochloride in rat feed

✍ Scribed by James E. Carter; John S. Dutcher; Daniel P. Carney; Lawrence R. Klein; Lawrence A. Black; Paul W. Erhardt

• Publisher: John Wiley and Sons
• Year: 1980
• Tongue: English
• Weight: 269 KB
• Volume: 69
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600691224

✦ Synopsis

An extraction and GLC assay procedure was developed for quantitation of procainamide hydrochloride and acecainide hydrochloride in rat feed. 4-Amino-N-[2-(dipropylamino)ethyl]benzamide hydrochloride was synthesized and utilized as an internal standard. The assay has good precision and accuracy and was used to establish the stability of acecainide hydrochloride and procainamide hydrochloride in rat feed.