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Analysis of heparin, α-dystroglycan and sulfatide binding to the G domain of the laminin α1 chain by site-directed mutagenesis

✍ Scribed by Zeynep Andac; Takako Sasaki; Karlheinz Mann; Andrea Brancaccio; Rainer Deutzmann; Rupert Timpl


Book ID
115629175
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
368 KB
Volume
287
Category
Article
ISSN
0022-2836

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Identification of a heparin binding site
✍ Ichiro Yoshida; Ken-Ichiro Tashiro; Akira Monji; Isao Nagata; Yoshihito Hayashi; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 342 KB

The carboxy-terminal globular domain (G-domain) of the laminin ␣1 chain has been shown to promote heparin binding, cell adhesion, and neurite outgrowth. In this study, we defined the potential sequences originating from the G-domain of laminin ␣1 chain which possess these functional activities. A se