## Abstract The ability to detect or reject genetic linkage in studies of human cancer is often diminished because multiple affected relatives in a pedigree are unavailable for analysis. The observation of somatic allele loss in tumors can provide knowledge about gametic phase. Therefore, considera
Analysis of Genetic Linkage and Somatic Loss of Heterozygosity in Affected Pairs of First-Degree Relatives
✍ Scribed by K. Rohde; M.D. Teare; M. Santibáñez Koref
- Book ID
- 117855066
- Publisher
- American Society of Human Genetics
- Year
- 1997
- Tongue
- English
- Weight
- 99 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/514849
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We conducted linkage analysis of 64 multiple-case families with early-onset bilateral breast cancer using DNA markers on chromosome band 1p36. Evidence against tight linkage was obtained using a dominant model for transmission (summary LOD scores at recombination fraction ϭ 0.000001 were -4.71 for D