𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Analysis of drug residues in tissue by combined supercritical-fluid extraction-supercritical-fluid chromatography-mass spectrometry-mass spectrometry

✍ Scribed by Edward D. Ramsey; John R. Perkins; David E. Games; James R. Startin

Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
647 KB
Volume
464
Category
Article
ISSN
1873-3778

No coin nor oath required. For personal study only.

✦ Synopsis

The combination of supercritical-fluid extraction-supercritical-fluid chromatography-tandem mass spectrometry has been evaluated for the detection of residues of a small group of veterinary drugs in freeze-dried pig's kidney. During extraction with supercritical CO2 the drugs were retained by the column while non-polar endogenous material was not retained and thus passed to waste. Subsequent changes to the mobile phase composition eluted the drugs which were detected with high specificity by tandem mass spectrometry. Although the sensitivity in this preliminary study was not adequate for surveillance or enforcement, there is potential for further development of the approach.

πŸ“œ SIMILAR VOLUMES

Supercritical fluid chromatography-mass
Supercritical fluid chromatography-mass spectrometry for chemical analysis
✍ Fangbiao Li; Yunsheng Hsieh πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 788 KB

## Abstract Chromatography with a supercritical fluid as the mobile phase was suggested more than four decades ago (Klesper, E., Corwin, A. H., Turner, D. A., __J. Org. Chem__. 1962, __27__, 700–701). Supercritical fluid chromatography (SFC) is basically a hybrid of GC and LC that eases the resolut

Supercritical fluid chromatography and s
Supercritical fluid chromatography and supercritical fluid chromatographyβ€”mass spectrometry of marine diesel fuel
✍ Bob W. Wright; Harold R. Udseth; Richard D. Smith; Robert N. Hazlett πŸ“‚ Article πŸ“… 1984 πŸ› Elsevier Science 🌐 English βš– 554 KB

The application of capillary column supercritical fluid chromatography (SFC) and supercritical fluid chromatography-mass spectrometry (SFC-MS) to the analysis of the polycyclic aromatic hydrocarbon fraction of selected marine diesel fuel samples is described. The chromatographic separation methods u

Determination of Volatile and Semivolati
Determination of Volatile and Semivolatile Contaminants in Meat by Supercritical Fluid Extraction/Gas Chromatography/Mass Spectrometry
✍ Snyder, Janet M; King, Jerry W; Nam, Ki-Souk πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 512 KB

Meat products that were exposed to a warehouse fire were collected and examined to identify contaminants present in the samples. An extraction method using supercritical carbon dioxide at 100 atm and 60Β°C was developed to analyse and characterise volatile and semi-volatile compounds from the samples

Analysis of conjugated bile acids by on-
Analysis of conjugated bile acids by on-line supercritical fluid chromatography/thermospra mass spectrometry
✍ Santo Scalia; David E. Games πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 421 KB

A rapid method was developed for the analysis of polar conjugated bile acids by combined packed column supercritical fluid chromatography/mass spectrometry. Direct coupling of the column to the mass spectrometer was effected with a modified thermospray interface operated in the filament-on mode. Max