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Analysis of Chinese hamster ovary cell metabolism through a combined computational and experimental approach

✍ Scribed by Chen, Ning; Bennett, Mark H.; Kontoravdi, Cleo


Book ID
121596347
Publisher
Springer
Year
2013
Tongue
English
Weight
735 KB
Volume
66
Category
Article
ISSN
0920-9069

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Chinese hamster ovary (CHO) cells were exposed to 2-acetylaminofluorene (2-AAF) and 2-aminofluorene (2-AF), and several of their N-oxidized metabolites in order to study the mechanisms by which arylamides and arylamines produce mutations in mammalian cells. The number of mutations induced at the hyp