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Analysis of candidate gene co-amplification with MYCN in neuroblastoma

โœ Scribed by R.E George; R Kenyon; A.G McGuckin; N Kohl; P Kogner; H Christiansen; A.D.J Pearson; J Lunec

Book ID
117663932
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
856 KB
Volume
33
Category
Article
ISSN
0959-8049

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MYCN gene amplification is strongly correlated with poor prognosis in neuroblastoma (NB), the second most common solid pediatric tumor. However, increased MYCN expression seen in tumors that lack MYCN amplification does not correlate with aggressive clinical behavior. Whereas the MYCN gene spans onl

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A DEAD box gene (DDXI) characterized by a motif with a putative RNA helicase was found at elevated levels, with multiple copies, in a neuroblastorna and in some retinoblastoma cell lines in which the MYCN gene was amplified. The present study was aimed at determining whether amplification o f the DD