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Genes co-amplified with MYCN in neuroblastoma: silent passengers or co-determinants of phenotype?

✍ Scribed by Debbie Scott; Joanna Elsden; Andrew Pearson; John Lunec

Book ID: 117467737
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 198 KB
Volume: 197
Category: Article
ISSN: 0304-3835
DOI: 10.1016/s0304-3835(03)00086-7

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MYCN gene amplification is strongly correlated with poor prognosis in neuroblastoma (NB), the second most common solid pediatric tumor. However, increased MYCN expression seen in tumors that lack MYCN amplification does not correlate with aggressive clinical behavior. Whereas the MYCN gene spans onl