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Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys

✍ Scribed by Arnsten, A.F.T.; Goldman-Rakic, P.S.


Book ID
121948455
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
774 KB
Volume
11
Category
Article
ISSN
0197-4580

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A selective alpha-2 agonist medetomidine, a selective alpha-2 antagonist atipamezole and lidocaine were injected into the prefrontal cortex of aged rats that had been trained to perform a delayed alternation (DA) task in a T maze. Medetomidine at the dose of 0.01 /zg//zl improved the memory task per