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Analyses of the 500 MHz 1H spectra of the 3-Methyl ethers of estrone, estradiol and their 14α-methyl analogues

✍ Scribed by Karl Bischofberger; James R. Bull; Anthony A. Chalmers

Book ID
102523722
Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
390 KB
Volume
25
Category
Article
ISSN
0749-1581

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✦ Synopsis

The 500 MHz 'H spectra of the 3-methyl ethers of estrone, estradiol and their 14a-methyl analogues were assigned by proton decoupling and analysed by second-order calculations for chemical shifts and coupling constants. Introduction of a 14a-Me group effects consistent deshielding of 1,3 diaxially disposed protons. Coupling constant values show characteristic changes for ring D protons, and suggest that some minor perturbation in the H-9a, -lla, -1lp region is caused by the additional methyl group.

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