Assignment and analysis of the 500 MHz 1H NMR spectra of somatostatin and the acyclic precursor (S3,14-Acm)-somatostatin in dimethyl sulphoxide

✍ Scribed by C. Deleuze; W. E. Hull

• Book ID: 102525525
• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 332 KB
• Volume: 18
• Category: Article
• ISSN: 0749-1581
• DOI: 10.1002/mrc.1270180214

✦ Synopsis

Abstract

The 500 MHz ^1^H NMR spectra of somatostatin and the precursor, di‐S^3,14^‐acetamidomethyl dihydrosomatostatin, in dimethyl sulphoxide solution have been assigned. Chemical shifts, coupling constants and NH shifts vs temperature coefficients are tabulated. The data are consistent with a stable β‐turn/β‐sheet conformation for the precurso, while somatostatin itself appears to be more conformationally mobile, with an average conformation significantly different from that in aqueous solution.