✦ LIBER ✦

Analogs of the anorexic mazindol

✍ Scribed by T. L. Lemke; L. A. Cates; M. Steenberg; Y. M. Cho

Publisher: John Wiley and Sons
Year: 1975
Tongue: English
Weight: 440 KB
Volume: 64
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600640824

No coin nor oath required. For personal study only.

✦ Synopsis

Mazindol, 5-(p-chlorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol, has been shown to be an effective anorexic. To explore the structure-activity relationships, several 1-ethyl-3-substituted-4-aryl-4-hydroxyindeno[1,2-c]pyrazoles were prepared and subjected to various animal screens. The 1-ethyl-3-tert-butyl-4-aryl-4-hydroxyindeno[1,2-c]pyrazoles are capable of significantly depressing forced and spontaneous motor activity in mice but have low LD50's. Two of these compounds were tested in an Ehrlich ascites tumor screen. The 1-ethyl-3-phenyl-4-aryl-4-hydroxyindeno[1,2-c]pyrazoles depressed forced and spontaneous motor activity at low doses and were relatively nontoxic.

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